Array 2-Cyrex Labs Leaky gut test

Cyrex Labs Leaky Gut test in India

Cyrex Labs is the World’s leading immunological/intolerance laboratory in the world. The Array 2 was specifically designed to measure antibodies that appear when the integrity of the intestinal wall is compromised.

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Cyrex Labs Leaky Gut test/Intestinal Permeability (Array 2)

Cyrex Labs is the World’s leading immunological/intolerance laboratory in the world. The Array 2 was specifically designed to measure antibodies that appear when the integrity of the intestinal wall is compromised.
Leaky gut or intestinal permeability is a frequently occurring condition in the modern world. As the name implies, the Leaky gut is a condition where the intestinal wall lets undigested food particles or other improper substances pass into the bloodstream.

There are a few known antigens present in with Intestinal permeability and those include Actomyosin, Occludin, Zonulin, and Lipopolysaccharides (LPS). These tests for different kinds of Leaky gut and will give a few hints about the possible causes.

LPS are large molecules found in gram-negative bacteria. They are endotoxins and trigger a strong immune response if absorbed. This reveals macromolecule-sized infiltration through the intestinal barrier into the systemic circulation.

Occludin is part of the main component of proteins holding together tight junctions (that connect individual intestinal wall cells to each other). The detection of Occludin antibodies suggests that tight junctions are breaking down. This shows the mechanism involved in damaging the intestinal barrier membrane.

Zonulin is the protein that directly regulates the permeability of the intestine. Antibodies to zonulin indicate compromised tight junction regulation. This can be a clue to the presence of an ongoing mechanism involved in damaging the intestinal barrier.

Actomyosin forms a protein complex that regulates the intestinal barrier function by maintaining tight junctions. This measures the mechanism involved in damaging the intestinal barrier.

Cyrex labs measure 7 different antigens that are indicative of leaky gut.

The best test for leaky gut

Why is Cyrex Labs Array 2 the best test for Leaky Gut?

The other option most widely used today is the Lactulose/Mannitol test and it’s been a helpful tool in the past 40 years. In this test, you drink a solution of Lactulose and Mannitol and they measure its levels in urine or blood.

Lactulose absorption suggests a “tear” in the gut barrier and thus intestinal permeability and here are the first misconceptions as this indicates minute leak rather than a tear. Lactulose has a low molecular weight and does not reflect food protein and immune response. The second problem with this test is that it measures only the transfer or small molecules through the paracellular but not the transcellular pathway.

Cyrex Array 2, therefore, measures food like size molecules that trigger immune responses and includes both, paracellular and transcellular pathways.

In essence Leaky gut is the passage of undigested food proteins or other unattended molecules through the intestinal barrier into the bloodstream. Such molecules are then regarded as pathogenic and an immune response is mounted against them even if they are harmless.

Research confirms that the root cause for many of undesired immune reactions originates in the gastrointestinal tract. GI tract abnormality can compromise the integrity of the gut barrier and increases the entry of undigested antigens into the sub-mucosa and the circulation, thus challenging the immune system. Reaction to these antigens activates immune and inflammatory cascades, resulting in the production of pro-inflammatory cytokines and an array of antibodies, which further contributes to increased intestinal barrier permeability (or “ leaky gut” syndrome).

The exaggerated entrance of antigenic macromolecules across the gut epithelium can initiate production of, and perpetuate an ongoing increase in, multiple inflammatory cytokines and systemic chronic inflammation. This appears to be a required component for the trio of factors that lead to eventual autoimmune disease (genetic vulnerability, environmental exposure, and intestinal permeability).

The single-cell epithelial lining in the intestines forms an amazingly large surface area (300-m2, about the size of a tennis court), which represents the single largest interface between our bodies and the external environment. The function of the intestinal mucosa is far more than just transportation of nutrients; it balances the needs for a barrier against a hostile environment, like the skin, with the necessity of active and passive transport, like the renal tubule. The intestinal mucosal cells favor fluxes of nutrients, regulate ion and water movements, and limit host contact with the massive intraluminal load of dietary antigens and microbes. An intact intestinal barrier is, therefore, critical to normal physiological function and the prevention of disease.

Intestinal permeability pathways

Depending on the damage either to the intestinal epithelial cells, unwanted molecules can pass directly through the sell or in between them (if the tight junctions are compromised).

Cyrex Array 2 measures both intestinal permeability pathways.

This test is suitable for everybody that suspects they may have Leaky gut.

It’s best suited for patients who:

  • Present with multiple symptom complaints (including Chronic Fatigue Syndrome).
  • Suffer from abnormal immune cell count and function (including autoimmune diseases).
  • Have multiple food sensitivity.

It is hard to pinpoint exact symptoms as leaky gut manifests in different diseases. Intestinal permeability is connected to:

  • Gluten Sensitivity and Celiac disease
  • Food Allergies
  • Inflammatory bowel disease (Ulcerative Colitis and Crohn’s disease)
  • Numerous autoimmune diseases (Rheumatoid Arthritis, Psoriasis, Type 1 Diabetes, Spondylitis, etc.)
  • Neurological conditions (Multiple Sclerosis, Guillain Barré Syndrome, etc.)
  • Cognitive Dysfunction (depression, anxiety, Schizophrenia, etc.)
  • Others
  • People that are more likely to have Leaky gut have:

    • A family history of connected diseases
    • Dysbiosis43 and microorganism invasions of (bacteria, yeast, viruses, parasites)
    • Traumas including surgical and non-surgical lesions
    • Stress due to disease, starvation, sustained strenuous exercise, radiation
    • Other environmental factors such as medications, allergenic foods
    • Current or past use of antibiotics, steroids, NSAIDs
    • History of chemotherapy or radiation treatment
    • History of chronic yeast infection
    • Digestive enzyme insufficiencies
    • Diet history of:
      • Standard American Diet
      • low fiber diets
      • excessive alcohol or caffeine consumption
      • unknown exposure to food allergens used as fillers in cosmetics, medications, nutrients

Cyrex Labs is an advanced clinical laboratory focusing on mucosal, cellular, and humoral immunology and specializing in antibody arrays for complex thyroid, gluten, and other food-associated autoimmunities and related neurodysregulation. Cyrex’s Scientific Advisory Board, comprised of experts from a variety of medical and research disciplines, brings together the latest findings from medical research and the assessment needs of today’s healthcare professionals. Out of this collaboration, Cyrex develops the next generation of clinical lab testing that is required to care for present-day complex maladies.

Cyrex’s Four Pillars of Excellence:

Antigen Purification System™ – ensures assessment of the un-adulterated antigen, resulting in greater specificity.

Optimized Antigen Concentration™ – optimum protein ratios to detect immune reactivity (i.e. Beef is much higher in protein than Oranges).

Antigen-Specific Validation™ – single antigen validation, rather than one arbitrarily chosen reference curve entire group of antigens.

Parallel Testing Technology™ – each specimen is validated in side-by-side duplicate.

Together, the Four Pillars of Excellence ensure accurate results.

 

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