Array 4 – Gluten-Associated Cross-Reactive Foods & Foods Sensitivity

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Cyrex Labs Gluten-Associated Cross-Reactive Foods & Foods Sensitivity (Array 4)

Cyrex Array 4 was specifically designed to help patients identify other frequently problematic food while having gluten sensitivity.

Unfortunately, intolerance seldom comes alone. There have been 28 allergens identified commonly causing problems in Celiac disease or non-celiac gluten sensitivity. If you have a known gluten intolerance, chances are you have negative immune reactions to those foods and should avoid them to improve and stay healthy. Actually this cross-reactivity is the single most important reason why such patients are not responsive or experience only limited improvements on a gluten-free diet.

If you know you have a problem with gluten, this is the most important next step in getting 100% fit and healthy.

What foods are being tested in this test?

Cyrex Array 4 is testing the following foods:

  • Grains: Barley, Millet, Oats, Polish wheat, Rice, Rye, Sorghum, Spelt, Teff.
  • Dairy products: Cow’s milk, Alpha-casein, Beta-casein, Casomorphin, Milk ButyrophIlin, Whey protein, Milk chocolate.
  • Pseudocereals and seeds: Amaranth, Buckwheat, Hemp, Quinoa, Sesame, Tapioca.
  • Other: Instant Coffee, Corn, Eggs, Potatoes, Soy, Yeast.

The next step in wheat/gluten intolerance

Why is Cyrex Labs Array 4 the best next step after confirmed gluten intolerance?

Patients with Gluten-Reactivity or Celiac disease are sensitized to a broad range of dietary proteins, due to enzyme dysfunction, villi damage, or other disorders. Therefore, it is crucial to identify not only sensitivities to foods that are often recommended for patients on the Gluten-free diet but also the food antigens that cross-react to gluten peptides in the patient. Without biochemically individualized dietary intervention, you may develop additional sensitivity/intolerance and autoimmunity. Although the majority of individuals with celiac disease have substantial improvement within the first few weeks of gluten withdrawal, between 7% and 30% continue to have symptoms or clinical manifestations suggestive of gluten sensitivity despite being on a gluten-free diet.

Cyrex Labs test for 28 such common allergens through their 4 pillars of excellence, giving you the ability to take new control of your disease and symptoms.

What is Gluten cross-reactivity?

Once a patient is diagnosed as Celiac Disease (CD) or having Gluten Reactivity, he/she is instructed to adhere to a gluten-free diet. However, a significant percentage (up to 30%) of these patients will continue to have gluten-like complaints even after being on a gluten-free diet(GFD) for months.

Most countries define “gluten-free” as below 0.3% protein from gluten-containing grains in foods. If the sensitive body is exposed to 0.3% protein, the immune system will recognize and react to the protein. There exists antigenic similarity, or cross-reaction, among many grains, and other dietary proteins such as casein with gluten. Based on the biological individuality of immune response against a repertoire of gliadin or gluten peptides, any number of patients may produce antibodies against a single gluten antigen or a combination of gluten antigens, some of which may be cross-reactive with other food antigens. Casein in particular, maybe a problem in about 50% of patients with CD.

Additionally, patients who are new to the GFD encounter new foods and/or over-consume old favorites to compensate for the lack of wheat in the diet. Gluten-free cookies, crackers, bread, and cakes often contain copious amounts of rice, amaranth, sorghum, and other substitutes. Some of these new-to-the-patient foods may elicit an adverse reaction.

This can lead to the development of a new sensitivity or the enhancement of old sensitivities.

3 types of antigen groups in gluten sensitivity

Taking this into account there are 3 types of sensitivity problems while having gluten intolerance:

  1. Unknown ingestion of actual gluten in “gluten-free” labeled food that exaggerates or cause additional intolerance.
  2. Overconsumption and introduction of new wheat-replacing foods (usually other grains) that cause new sensitivities and symptoms.
  3. Actual cross-reactivity with other foods because of compositional similarities in protein structure to gluten (in this case your immune system thinks a protein is gluten and marks it for destruction).

Array 4 can detect both sensitivities and cross-reactions and thus reveal the possible cause of this continued gluten-like reaction.

As this allergens are commonly reactive in gluten-sensitive people, everybody with a known or suspected Gluten sensitivity or Celiac disease will benefit in taking this test.

Also people that have gut dysbiosis, which appears to be resistant to standard therapy can benefit from this test.

And most importantly if you are experiencing limited improvements or are non-responsive on a gluten-free diet this test will identify most common foods that could be making you sick and impair your improvement.

You should also consider this test if you have an autoimmune issue.

Cyrex Labs is an advanced clinical laboratory focusing on mucosal, cellular, and humoral immunology and specializing in antibody arrays for complex thyroid, gluten, and other food-associated autoimmunities and related neurodysregulation. Cyrex’s Scientific Advisory Board, comprised of experts from a variety of medical and research disciplines, brings together the latest findings from medical research and the assessment needs of today’s healthcare professionals. Out of this collaboration, Cyrex develops the next generation of clinical lab testing that is required to care for present-day complex maladies.

Cyrex’s Four Pillars of Excellence:

Antigen Purification System™ – ensures assessment of the un-adulterated antigen, resulting in greater specificity.

Optimized Antigen Concentration™ – optimum protein ratios to detect immune reactivity (i.e. Beef is much higher in protein than Oranges).

Antigen-Specific Validation™ – single antigen validation, rather than one arbitrarily chosen reference curve entire group of antigens.

Parallel Testing Technology™ – each specimen is validated in side-by-side duplicate.

Together, the Four Pillars of Excellence ensure accurate results.

 

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